Endocrine Abstracts

In clinical trials, the SGLT2 inhibitor Canagliflozin inhibits renal reabsorption of glucose, increases its excretion and reduces hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). The increase in glucosuria and diuresis produced, results in a reduction in weight and blood pressure (BP). Moreover, It may cause genital and urinary tract infections. However, does Canagliflozin behave in the same way in routine clinical practice?Objective: To ...

Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It has been defined by an absence of overt Cushing’s syndrome (CS) signs (no skin weakness, muscle atrophy, or osteoporosis) associated with biological hypercortisolism consisting of high urinary free cortisol (UFC) and an absence of negative feedback loop of cortisol on HPA, defined as 8-AM cortisol level >50 n...

Background: Primary bilateral bilateral macronodular adrenal hyperplasia is a cause of Cushing’s syndrome. It is characterised by a large enlargement of the adrenal glands at the expense of multiple non-pigmented nodules. There is inefficient steroidogenesis.Summary of the case: A 58-year-old woman with a history of extreme obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia was admitted to our hospital for cellulitis and anaemia secon...